Retatrutide is a triple agonist peptide that activates GLP-1, GIP, and glucagon receptors. This action helps regulate appetite, slow digestion, improve insulin sensitivity, and increase energy expenditure, leading to significant weight loss and improved metabolic health.

Retatrutide is extremely powerful, and the goal is appetite management, not appetite elimination. Killing all hunger entirely is dangerous and counterproductive. Only move to the next step if hunger is still unmanageable at your current dose — do not chase a higher number.

Administered once weekly. Specific timing relative to meals or time of day is not critical, but consistency on the same day each week is advised.

Clinical trials have shown efficacy over 48 weeks. There is no explicit cycling protocol defined in current research; it appears to be used continuously.

BPC-157 is a synthetic peptide derived from a protein found in human gastric juice. It promotes healing by activating the VEGFR2-Akt-eNOS pathway, which is involved in blood vessel formation and tissue repair. It shows high efficacy in animal models for various injuries.

A common starting point for beginners is 250 mcg once daily, increasing to 500 mcg if well tolerated.

Take at a consistent time each day. No specific timing relative to meals is required.

Typically 4–8 weeks on, followed by 2–4 weeks off. For acute injuries, run a full 8-week cycle. For general maintenance, 4 weeks on / 2 weeks off is common.

TB-500 is a synthetic peptide that mimics thymosin beta-4, a naturally occurring protein crucial for cell migration, differentiation, and survival. It works by regulating actin, facilitating cell migration for wound healing, promoting new blood vessel formation, and reducing inflammation.

TB-500 is typically used in two phases:

Injections are typically administered on specific days of the week, regardless of meals or workouts.

Loading phase of 4 weeks, followed by a maintenance phase of 4–8 weeks, then a break of 2–4 weeks before repeating.

KPV is a naturally occurring tripeptide that modulates the immune system and reduces inflammation by inhibiting the activation of NF-κB, a key protein involved in inflammatory responses. This helps lower overall inflammation, improve immune function, and promote wound healing.

All doses are subcutaneous injection. Increase gradually as tolerated.

Daily administration. Timing relative to meals or sleep is flexible.

Generally considered safe for long-term use. Some individuals cycle 4–8 weeks to maintain efficacy; those with chronic conditions may use it for longer durations.

SS-31 (Elamipretide) specifically targets the inner mitochondrial membrane, improving mitochondrial function, restoring cellular energy balance, and protecting cells from damage. This leads to enhanced energy production, improved cellular health, and increased exercise tolerance.

All doses are subcutaneous injection.

Can be taken at any consistent time of day, regardless of meals or workouts. Morning is most common.

8–12 weeks on; cycling is recommended for durations beyond 12 weeks. Take a 4-week break between cycles.

MOTS-c is a peptide derived from mitochondria that regulates energy metabolism by enhancing insulin sensitivity, promoting fat oxidation, and influencing the AMPK pathway, which helps cells utilize glucose more effectively.

All doses are subcutaneous injection. Administer 30–45 minutes before a meal or fasted in the morning.

Administer 30–45 minutes before the largest meal of the day, or in the morning fasted for best metabolic effect.

4–8 weeks on, 2–4 weeks off. Cycling is recommended to prevent metabolic adaptation.

NAD+ (Nicotinamide Adenine Dinucleotide) is a vital molecule present in every cell, crucial for converting food into energy. It acts like a shuttle, moving electrons to power cellular processes, supporting DNA repair, metabolism, and protecting cells from stress.

All doses below are for subcutaneous injection. Start low and build up gradually — NAD+ can cause a flushing or warm sensation if you go too fast.

Morning administration is recommended, as NAD+ supports cellular energy production and aligns with the body's natural energy cycles. Can be taken with or without food.

Cycling is generally not recommended. NAD+ is continuously consumed by the body and consistent supplementation is preferred.

Tesamorelin is a synthetic GHRH analogue that stimulates the body's natural production and release of growth hormone from the pituitary gland. This increased GH primarily reduces excess visceral fat and supports healthy body composition and metabolism.

All doses are subcutaneous injection. Always pair with Ipamorelin — do not use alone.

Recommended in the evening before sleep, to align with the body's natural growth hormone release rhythm.

A common cycling protocol involves a 3-month active treatment course, followed by a 4-week rest period before repeating. Some protocols suggest 5 days on / 2 days off each week during the active cycle.

MT-2 is a synthetic peptide that mimics alpha-melanocyte-stimulating hormone (α-MSH). It stimulates melanocytes — cells responsible for producing melanin — leading to increased skin pigmentation. It also activates melanocortin receptors in the brain, influencing libido.

All doses are subcutaneous injection.

Injections are typically administered once daily during the initial tanning phase. Many users inject in the evening to minimize nausea during waking hours.

An initial tanning cycle typically lasts 6–8 weeks. After achieving the desired tan, switch to a maintenance phase of 1–2 injections per week to sustain pigmentation.

Semax is a synthetic nootropic peptide derived from an ACTH fragment. It works by increasing brain-derived neurotrophic factor (BDNF) and influencing dopamine and serotonin levels, supporting memory, focus, neuroplasticity, and neuroprotection.

Start at 100–200 mcg once daily and assess your response before increasing. Effects are often noticeable at low doses.

Typically taken in the morning to support focus and productivity. Avoid evening administration to prevent disrupted sleep.

10–20 days on, followed by a break of 5–10 days. Cycling is necessary to prevent tolerance.

Selank is a synthetic neuroactive peptide that promotes calmness and emotional stability by modulating GABA and serotonin, increasing BDNF, and reducing stress hormones like cortisol. It reduces anxiety and improves cognitive function without causing sedation or dependence.

Each nasal spray delivers approximately 100–150 mcg. A common starting protocol is 1–2 sprays in the morning and 1 spray in the afternoon.

Take in the morning for focus and calm, and in the afternoon for stress support. Avoid late-night use if sensitive. The total daily dose is often divided into multiple sprays throughout the day.

10–20 days on, followed by a 5–10 day break. Short cycles can be 10–14 days; extended cycles can last up to 30 days.

5-Amino-1MQ inhibits the enzyme Nicotinamide N-methyltransferase (NNMT). By blocking NNMT, it prevents the degradation of nicotinamide (a NAD+ precursor), shifting cellular metabolism away from fat storage and toward fat burning while preserving lean muscle mass.

All doses are subcutaneous injection.

SubQ injections are often preferred in the morning. Oral doses are typically split throughout the day to maintain stable blood levels.

4–6 weeks on, followed by 2–4 weeks off. Continuous use without breaks is not recommended as effects may diminish over time.

PT-141 (Bremelanotide) is a melanocortin receptor agonist that activates receptors in the hypothalamus — the part of the brain responsible for sexual motivation. This directly increases sexual desire, heightens arousal, and enhances physical pleasure and sensation through the central nervous system rather than through blood flow. This brain-based mechanism is why it is so uniquely effective for women, whose sexual response is far more neurologically driven than mechanically driven.

All doses are subcutaneous injection. Do not use more than once every 3–4 days.

Administer at least 45 minutes to 2 hours before anticipated sexual activity. Effects can last 4–12 hours, with peak action typically occurring 2–3 hours post-administration. Plan ahead — this is not a last-minute peptide.

Do not use more than once every three to four days to prevent receptor adaptation and diminishing effects. No formal cycling protocol is required beyond this frequency recommendation.

Epithalon is a synthetic tetrapeptide that acts as a telomerase activator — an enzyme crucial for maintaining and lengthening telomeres. By stimulating telomerase activity, it helps protect cellular DNA and supports healthy cell division. It also stimulates melatonin synthesis and helps regulate circadian rhythms.

All doses are subcutaneous injection.

Evening administration is often recommended, or divided into two daily doses (morning and evening).

Typically administered for 10–20 consecutive days. This cycle can be repeated once or twice per year, with a 4–6 month break between cycles.

GHK-Cu is a naturally occurring copper complex that promotes skin remodeling, wound healing, and regeneration. It also exhibits prominent antioxidant and anti-inflammatory effects, contributing to its anti-aging and restorative properties.

Typically administered once per day. Evening administration is common. Timing relative to meals is flexible.

30 days on, 30 days off is the most common protocol. Some use 7–8 week cycles followed by a rest period.

DSIP is a neuropeptide that helps regulate sleep by promoting deep delta sleep and improving REM sleep architecture, leading to better sleep quality and reduced time to fall asleep. It also influences the body's stress response and pain perception.

All doses are subcutaneous injection, taken in the evening.

Administer in the evening, 30 minutes to 3 hours before bedtime. This timing aligns its effects with the natural sleep cycle.

8–12 weeks on. After completing a cycle, take a break to assess the body's response and prevent potential desensitization.

SLU-PP-332 is an exercise mimetic that acts as a potent agonist for estrogen-related receptor alpha (ERRα). By activating ERRα, it mimics the cellular and physiological effects of aerobic exercise, leading to increased energy expenditure and enhanced fat oxidation.

All doses are subcutaneous injection.

Can be taken in the morning; doses may be divided throughout the day. No specific requirements regarding meals or workouts.

4–12 weeks on, followed by a break of similar duration. Cycling is recommended due to potential metabolic adaptation.